Risk factors for development of aminoglycoside resistance among gram-negative rods

Aminoglycoside Resistance in Gram-negative Bacilli

Aminoglycosides are one of the clinically relevant antibiotics. They kill bacteria by binding to bacterial 30S subunit of ribosome. Resistance to aminoglycosides occurs by three different mechanisms: 1. Production of an enzyme that modifies aminoglycosides, 2. Impaired entry of aminoglycoside into the cell by altering the OMP permeability, decreasing inner membrane transport, or active efflux, ...

Antimicrobial Resistance among Gram-negative Bacilli

Polyclonal bacteremia due to gram-negative rods.

The frequency of, risk factors for, and outcome of polyclonal gram-negative bacteremia are still unknown. We investigated them in a prospective cohort study of patients for whom a blood culture yielded >/=1 species of gram-negative aerobic rod. For each patient, pulsed field gel electrophoresis (PFGE) was performed on 4 colonies of each morphologic type. Episodes of bacteremia were considered p...

risk factors associated with imipenem-resistance among isolated gram -negative bacteria from patients in sanandaj hospitals, iran

conclusions our results showed the rate of effects of different risk factors on imipenem resistance. regarding the studied risk factors, appropriate programs must be set in place to control and prevent imipenem resistance in gram-negative bacteria. results of the 374 isolated, 134 were imipenem resistant, and 240 were sensitive to imipenem. the resistance rate was more common in males and in pa...

Antibiotic Resistance Pattern of Gram-Negative Bacteria in Gorgan

Abstract Background and Objective: The excessive use of broad-spectrum antibiotics will lead to drug resistance of microorganism and specially nosocomial organisms. Because of high incidence of antibiotic resistance in hospitals, we aimed to study antibiotic resistance to gram negative bacteria. Material and Methods: This cross-sectional study was conducted on the data of biological sampl...